Botanical Essence offers high-purity Rotundine L-THP 98% (CAS 10097-84-4), a naturally derived isoquinoline alkaloid extracted from the tuber of Corydalis yanhusuo. Known for its exceptional quality and consistent performance, our L-Tetrahydropalmatine appears as a white to yellowish crystalline powder. It is odorless with a slightly bitter taste and exhibits characteristic sensitivity to light and heat, turning yellow upon prolonged exposure.
This premium extract is practically insoluble in water, slightly soluble in ethanol, and readily soluble in chloroform and ether. Its sulfate salt form demonstrates excellent water solubility, making it highly suitable for both solid and liquid dosage formulations.
Physicochemical Properties
- Appearance: White to yellowish crystal powder
- Purity: ≥98% (HPLC)
- CAS No.: 10097-84-4
- Molecular Formula: C₂₁H₂₅NO₄
- Solubility: Insoluble in water; highly soluble in chloroform and ether
- Stability: Stable under recommended storage conditions; protect from light and moisture
Key Functional Benefits
1. Central Nervous System Support
Rotundine L-THP is well-recognized in traditional and modern phytochemistry for its notable effects on the central nervous system. It exhibits moderate analgesic, sedative, and hypnotic properties. While milder than synthetic opioids such as pethidine, it demonstrates significantly stronger activity compared to common antipyretic analgesics. Additionally, it has been shown to reduce behavioral sensitization scores and effectively block the development of behavioral hypersensitivity.
2. Cardiovascular and Cerebrovascular Protection
Scientific studies have highlighted the compound’s protective role in ischemia-reperfusion models. In cerebral ischemia models, L-Tetrahydropalmatine can significantly prolong survival time, enhance the activity of superoxide dismutase (SOD) and lactate dehydrogenase (LDH), while decreasing malondialdehyde (MDA) and nitric oxide levels.
In myocardial ischemia-reperfusion experiments, Rotundine has demonstrated the ability to reduce the incidence of ventricular arrhythmias, lower plasma noradrenaline concentrations, and decrease serum creatine phosphokinase (CPK) activity following coronary artery ligation and reperfusion.
3. Cardiovascular Regulation
Rotundine exhibits dose-dependent hypotensive effects in animal models, accompanied by a transient reduction in heart rate. It also displays mild calcium channel antagonistic properties, reducing calcium channel current in ventricular myocytes and showing use-dependent blockade characteristics.
4. Additional Pharmacological Properties
Research indicates that Rotundine may help reverse multidrug resistance (MDR) in certain cancer cell lines, such as MCF-7, through downregulation of P-glycoprotein (P-gp) expression. It has also been observed to promote the secretion of pituitary adrenocorticotropic hormone (ACTH), thereby stimulating the pituitary-adrenal axis.
Applications in Nutraceutical and Pharmaceutical Formulations
As a versatile botanical active, Rotundine L-THP 98% is widely used by nutraceutical manufacturers, pharmaceutical developers, and contract formulators in:
- Dietary supplements targeting sleep support and stress relief
- Functional formulations for cardiovascular and neurological health
- Traditional herbal extract blends
- Research and development of natural sedative and analgesic ingredients
Formulation Compatibility
The compound is compatible with both tablet/capsule formats and injectable preparations (in sulfate salt form). Common commercial specifications include:
- Tablets: 30 mg and 60 mg
- Injection (sulfate): 2 mL : 60 mg
Quality Assurance & Supply Advantages
At Botanical Essence, every batch of Rotundine L-THP undergoes rigorous quality control following strict GMP standards. Our vertically integrated supply chain ensures full traceability from raw Corydalis yanhusuo tubers sourced from premium cultivation regions in China to the final high-purity extract.
We maintain stable inventory, consistent 98% purity, and reliable batch-to-batch consistency — critical factors for branded manufacturers, contract manufacturers, and international distributors seeking long-term supply partners.
Packaging & Storage
- Standard packaging: 1 kg aluminum foil bag, 25 kg fiber drum
- Storage: Keep in a cool, dry place away from light and moisture
- Shelf life: 24 months under proper storage conditions
Why Choose Botanical Essence as Your Rotundine L-THP Supplier?
Manufacturers and brand owners worldwide trust Botanical Essence for premium plant-derived active ingredients backed by technical expertise, regulatory support, and customer-centric service. Whether you require small trial orders or multi-ton commercial volumes, we provide competitive pricing, professional documentation, and responsive technical support.
For quotations, specifications, or custom formulation guidance, please contact our specialist team at [email protected].
Discover why leading nutraceutical and pharmaceutical companies choose Botanical Essence as their trusted partner for high-purity Rotundine L-THP and other premium botanical extracts.
