1. Introduction

Senna leaf extract serves as a popular herbal laxative utilized globally. It effectively clears internal heat and stagnation, supports bowel movements, and promotes diuresis. This extract is primarily indicated for managing heat-related constipation, stomach discomfort, swelling, and bloating. It is officially recognized in pharmacopeias across the United States, United Kingdom, India, China, Europe, and various other regions. In clinical settings, senna leaf extract is frequently applied for bowel preparation prior to rectal procedures or surgeries. It is derived from the dried foliage of Cassia angustifolia (narrow-leaf senna) or Cassia acutifolia (sharp-leaf senna), typically standardized to 3% or 5% total sennosides.

  1. Function

Laxative action: The infusion of senna is rich in anthraquinone compounds, delivering a more potent purgative effect and greater stimulation than many alternative laxatives.

Antimicrobial activity: Alcohol-based senna extracts demonstrate inhibition against multiple pathogens, including Staphylococcus, Corynebacterium diphtheriae, Salmonella typhi, Salmonella paratyphi, and Escherichia coli. Water extracts, however, primarily target Salmonella typhi.

Hemostatic properties: Senna powder elevates platelet counts and fibrinogen levels while shortening clotting time, recalcification time, prothrombin time, and clot retraction time, thereby assisting in bleeding control.

Muscle relaxation: Senna interferes with acetylcholine transmission at neuromuscular junctions, inducing skeletal muscle relaxation.

  1. Application

Senna leaf extract provides notable antibacterial effects and finds use in conditions such as acute pancreatitis, bacterial dysentery, epidemic hemorrhagic fever, cholecystitis, and postpartum milk production promotion.

Additionally, it is incorporated into dietary supplements and various other industries.

  1. Flow chart


  2. Specification


TestSpecificationsResult
Assay by UV≥8% sennosideComplies
AppearanceFine brown powderComplies
Odor & tasteCharacteristicComplies
Mesh size100% pass 80meshComplies
SolubilitySoluble wellComplies
Loss on drying %≤3.0%1.02%
Ash%≤0.5%0.17%
Heavy metals PPM<20ppmComplies
Microbiology
Total Plate Count<1000cfu/gComplies
Yeast & Mold<100cfu/gComplies
E.ColiNegativeComplies
S. AureusNegativeComplies
SalmonellaNegativeComplies

Conclusion: Meets in-house specifications.

  1. NMR


  2. MOA


  3. Stability and Safety


Stability: Remains stable under recommended storage at room temperature. Stability data sheets provided upon request.

Safety: Deemed Generally Recognized as Safe (GRAS) by the U.S. FDA, confirming its suitability for human consumption.


  1. Our Certificates

At Botanical Essence, we have consistently focused on enhancing production processes and developing stringent quality controls. Our comprehensive quality management system is fully certified.

  1. Our Clients

Botanical Essence maintains strong partnerships with renowned firms including Abbott, Unilever, Shiseido, KANS, and SIMM, among others.

  1. Exhibitions

Botanical Essence actively participates in key international trade events such as CPhI, FIC, API, Vitafoods, and SupplySide West.

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